Hepatocurative Effect of Some Ethnomedicinal Plants on Liver Function Indices in Alloxan- Induced Diabetic Rats

Aims: This research investigated the curative effects of Moringa oleifera (MO), Treculia africana (T.A.), and Albizzia chevalieri (A.C.) plant extracts on liver function indices in Alloxan-induced diabetic rats.
 Study Design: Albino rats were grouped into five (5) main groups MO, TA, A.C., Normal Control (N.C.), Diabetic (D.C.) groups.
 Place Duration Study: Department Science Laboratory Technology, Federal Polytechnic Kaura Namoda, between May 2021 July 2021.
 Methodology: Diabetes mellitus was caused by a single dose intraperitoneal injection Alloxan 150 mg/kg body weight. Liver determined using standard methods.
 Results: Intraperitoneal albino resulted significant (p<0.05) increase Aspartate aminotransferase (AST), Alanine (ALT) Alkaline phosphatase (ALP) activities, Direct Total bilirubin while total protein concentration significantly decreased when compared with that non-diabetic (N.C.) group. Oral administration A.C. to for 21 days AST, ALT, ALP direct concentration. While increased diabetes-treated groups. Histopathological studies confirmed toxic effect induced hepatocurative studied medicinal plants. MO (800mg/kg) demonstrated most T.A. Possible mechanism plants may be due free radical scavenging potential extracts.
 Conclusion: In conclusion, results present study demonstrate oleifera, dose-dependent manner, has potent effect, followed chevalieri, then Trecullia Africana against damage.